Prenatal Environmental Determinants of Intergenerational Risk (PEDIGREE) is a sub- study of 3Gs. Like 3Gs, the PEDIGREE Study is studying how the environment might affect people's health and how it might play a role in the development of disease across generations. As with 3Gs, participation in this study does not involve medical treatment and therefore poses minimal risk.

The PEDIGREE Study will ask about 400 eligible second generation CHDS women (daughters) Study for permission to obtain a copy of their past mammogram film(s) from the facility where they received this service. The mammograms will be used to measure breast density. Breast density is a measureable indicator of breast health, and can indicate future risk of breast cancer. For more information on the PEDIGREE Study mammogram collection please click here.

The PEDIGREE Study may also be testing a blood or saliva sample to measure the amount of change in the chemical groups attached to the DNA. This test measures gene activity. This will not require another blood draw as the blood already collected for 3Gs or Disparities will be used. If you are not participating in the 3Gs or Disparities in-person visit, we will send you an at-home saliva collection kit. We can get the same information in saliva.

The PEDIGREE Study will also be writing to about 100 CHDS daughters with a history of breast cancer for permission to obtain a copy of their breast cancer pathology report and tumor tissue sample. For more information on the PEDIGREE Study breast cancer pathology report and tumor tissue sample collection please click here.

You will be notified in the invitation letter we mailed to you which component(s) of PEDIGREE you are eligible to participate in.